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Fig. 1 | Molecular Medicine

Fig. 1

From: Noninvasive Dynamic Fluorescence Imaging of Human Melanomas Reveals that Targeted Inhibition of bFGF or FGFR-1 in Melanoma Cells Blocks Tumor Growth by Apoptosis

Fig. 1

Tumor volume of human melanomas, inoculated with Tyr-bFGF or Tyr-FGFR-1 antisense construct-liposome complexes. Nude mice were injected subcutaneously on their dorsal site with 5 × 106 MGP melanoma cells/animal. When the tumors had reached 5 mm in perpendicular diameter, they were inoculated with 100 µg of plasmid DNA, mixed with 10 nmol of DC-Chol liposomes, followed by twice weekly injections of 20 µg of plasmid DNA mixed with 10 nmol of DC-Chol liposomes. Perpendicular tumor diameters were measured daily. All animals were sacrificed on day 22 when the mice bearing control tumors reached the maximal allowable size of 2 cm in perpendicular diameter. (a) Volume of MGP melanomas injected with Tyr-bFGF antisense construct. (b) Volume of MGP melanomas that received Tyr-FGFR-1 antisense construct. Volumes of control tumors, which were not inoculated or had received pREP7 vector construct, not containing human bFGF or FGFR-1 antisense-oriented cDNA, are the same in both panels. Means are depicted, and standard error bars are shown for each group of tumors.

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Molecular Medicine

ISSN: 1528-3658