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Fig. 5 | Molecular Medicine

Fig. 5

From: Noninvasive Dynamic Fluorescence Imaging of Human Melanomas Reveals that Targeted Inhibition of bFGF or FGFR-1 in Melanoma Cells Blocks Tumor Growth by Apoptosis

Fig. 5

Tumor volume of melanomas upon cessation of Tyr-bFGF and Tyr-FGFR-1 plasmid injections. MGP melanomas were inoculated twice weekly with Tyr-bFGF or Tyr-FGFR-1 antisense construct-liposome complexes. On day 25, following the first injection of either vector construct, the injections were stopped and thereafter, tumor sizes were measured daily until day 40, when the animals were sacrificed. The arrow indicates the final day of intratumoral injections. Animals bearing uninjected control tumors were sacrificed on day 25 since their tumors had reached the maximal allowable size. Standard errors (not shown) were 0.26 for Tyr-bFGF and 0.14 for Tyr-FGFR-1 antisense construct-injected tumors.

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Molecular Medicine

ISSN: 1528-3658