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Table 1 Historical overview of ILA/IGFs expression in human neoplasms

From: The Role of Insulin-Like Growth Factor 2 and Its Receptors in Human Tumors

Type of Cancer ILA*/IGF Types Description References
Hodgkin’s lymphoma   - Overexpression of insulin-like activity (ILA) 3, 7, 8, 9
non-Hodgkin lymphomas ILA - Secretion by tumor cells proven in some cases  
Renal carcinoma insulin and glucagon - Ectopic secretion by tumor cells 4
Cervical and endometrial carcinomas IGF-1, IGF-1R - ILA*; recently obtained IGF1 and IGF1R overexpression 10 Unpublished
Bronchial and mammary carcinomas ILA - ILA*; autocrine secretion 5 6
Lung cancer IGF-2, IGF-1R, IGF-2R - IGF-2, IGF-1R, and IFG-2R overexpression 11
Hemangiosarcoma IGF-1 - Autocrine growth stimulation 12
Hemangiopericytomas IGF-1 IGF-2 IGF-1R - Overexpression 13 14 15
Gastric cancer IGF-2 IGF-1R - Overexpression; autocrine secretion Unpublished
  1. *Insulin-like Activity Detected by Radioimmunoassay with insulin antibodies IGF-1, IGF-2, IGF-1R, and IGF-2R/M6P determined by RNAse protection assay, RT-PCR, or immunohistochemistry.