Table 1 Historical overview of ILA/IGFs expression in human neoplasms
From: The Role of Insulin-Like Growth Factor 2 and Its Receptors in Human Tumors
Type of Cancer | ILA*/IGF Types | Description | References |
|---|---|---|---|
Hodgkin’s lymphoma |  | - Overexpression of insulin-like activity (ILA) | 3, 7, 8, 9 |
non-Hodgkin lymphomas | ILA | - Secretion by tumor cells proven in some cases | Â |
Renal carcinoma | insulin and glucagon | - Ectopic secretion by tumor cells | 4 |
Cervical and endometrial carcinomas | IGF-1, IGF-1R | - ILA*; recently obtained IGF1 and IGF1R overexpression | 10 Unpublished |
Bronchial and mammary carcinomas | ILA | - ILA*; autocrine secretion | 5 6 |
Lung cancer | IGF-2, IGF-1R, IGF-2R | - IGF-2, IGF-1R, and IFG-2R overexpression | 11 |
Hemangiosarcoma | IGF-1 | - Autocrine growth stimulation | 12 |
Hemangiopericytomas | IGF-1 IGF-2 IGF-1R | - Overexpression | 13 14 15 |
Gastric cancer | IGF-2 IGF-1R | - Overexpression; autocrine secretion | Unpublished |