Fig. 1
From: Anx7 Is Required for Nutritional Control of Gene Expression in Mouse Pancreatic Islets of Langerhans
Physiologic and molecular properties of Anx7(+/−) mice, compared to normal Anx7(+/+) littermate controls. (A) Glucose tolerance test for Anx7(+/+) and Anx7(+/−) mice. Blood glucose levels were measured in seven pairs of control (a) and anx7 (+/−) (b) knockout mice littermates following a glucose challenge (2 g/kg IP) after 24 hr fasting. *p < 0.1, paired t-test versus control, Anx7 (+/+) male littermates. See Table 1 for summary. (B) Insulin tolerance test for Anx7(+/+) and Anx7(+/−) mice. Insulin levels were measured in control (a) and Anx7 (+/−) (b) knockout mice littermates following insulin challenge (1 U/kg IP) without fasting. *p < 0.1; **p < 0.05, paired t-test versus control, Anx7 (+/+) male littermates (n = 24 mice). (C) Inositol-trisphosphate receptor gene expression for Anx7(+/+) and Anx7(+/−) mice. Relative abundance of IP3 receptor types in control and mutant mice by RT-PCR. PCR conditions and the primer pairs used are as described in Materials and Methods.