Table 4 Effects of CFTR mutation and CPX on expression of available CF-relevant genes

Kinases and phosphatases

B5l

Protein-tyrosine kinase (JAK1)

0.39

0.19

0.19

10.42

8.20

2.7

45

B7f

Tyrosine kinase (Tnk1)

1.56

1.27

1.49

1.02

0.98

−0.3

240

B2i

Protein kinase C δ-type

1.18

0.70

0.49

0.68

0.51

−3.0

135

B5j

Protein kinase C (PKC) type β I

0.32

0.16

0.17

0.56

0.44

1.1

30

B5k

PKA subunit RII-β

0.24

0.16

0.16

1.32

0.95

1.8

45

B5m

PKA regulatory subunit RI-β

5.78

2.44

2.56

203.33

234.82

2.8

45

B6b

PKA catalytic subunit type α

3.39

5.94

6.25

2.78

2.95

0.7

225

B7g

Protein tyrosine phosphatase (CIP2)

0.26

0.24

0.23

0.35

0.27

−0.5

30

A5c

AXL tyrosine kinase receptor

1.52

4.16

14.67

1.54

7.18

0.8

210

B6n

Receptor tyrosine kinase ligand (LERK-3)

0.30

0.12

0.12

2.40

1.65

2.3

45

Heat shock proteins

B7l

Heat shock protein HSP27

1.83

1.56

1.19

4.50

2.39

0.9

30

B7i

Heat-shock protein 40

1.55

1.56

1.53

1.45

1.15

−0.9

255

B7j

Chaperonin (HSP60)

0.64

0.47

0.47

1.06

1.11

0.8

45

B7m

Heat shock protein (HSP 70)

0.47

0.37

0.16

0.81

0.52

1.0

60

B7k

Heat shock protein hsp86

0.31

0.17

0.19

1.76

2.41

2.1

45

Adenosine receptors

C1h

A2a adenosine receptor

0.53

0.68

0.53

0.55

0.43

−0.9

225

C1i

A1 adenosine receptor

3.01

3.22

2.27

2.17

1.06

0.4

240

C1j

A3 adenosine receptor

0.56

0.47

0.37

0.71

0.50

−0.3

30

Inflammatory

F2j

RANTES pro-inflammatory cytokine

9.30

32.49

45.30

23.54

51.80

−0.7

150

F6b

Interleukin-6 (IL-6) precursor

1.19

0.39

0.43

5.73

3.07

2.0

30

F6f

Interleukin-10 (IL-10)

4.16

4.64

7.42

5.02

2.59

0.6

270

Transcription factors

D2g

cAMP-responsive element-binding protein

1.17

1.28

1.10

0.70

0.67

0.3

225

B3a

NFκB transcription factor p65 subunit

0.56

0.39

0.33

0.79

0.62

0.5

45

Miscellaneous

A5i

MUC18 glycoprotein

0.59

0.27

0.50

0.45

1.17

0.6

60

C4l

Caspase-9 precursor

1.50

1.07

1.27

8.36

4.76

1.7

30