Expression Levela | CPX Vector | |||||||
---|---|---|---|---|---|---|---|---|
Location | Name of Gene | HEK | wt | ΔF | wt + CPX | ΔF + CPX | Length (S)b | Angle |
Kinases and phosphatases | ||||||||
B5l | Protein-tyrosine kinase (JAK1) | 0.39 | 0.19 | 0.19 | 10.42 | 8.20 | 2.7 | 45 |
B7f | Tyrosine kinase (Tnk1) | 1.56 | 1.27 | 1.49 | 1.02 | 0.98 | −0.3 | 240 |
B2i | Protein kinase C δ-type | 1.18 | 0.70 | 0.49 | 0.68 | 0.51 | −3.0 | 135 |
B5j | Protein kinase C (PKC) type β I | 0.32 | 0.16 | 0.17 | 0.56 | 0.44 | 1.1 | 30 |
B5k | PKA subunit RII-β | 0.24 | 0.16 | 0.16 | 1.32 | 0.95 | 1.8 | 45 |
B5m | PKA regulatory subunit RI-β | 5.78 | 2.44 | 2.56 | 203.33 | 234.82 | 2.8 | 45 |
B6b | PKA catalytic subunit type α | 3.39 | 5.94 | 6.25 | 2.78 | 2.95 | 0.7 | 225 |
B7g | Protein tyrosine phosphatase (CIP2) | 0.26 | 0.24 | 0.23 | 0.35 | 0.27 | −0.5 | 30 |
A5c | AXL tyrosine kinase receptor | 1.52 | 4.16 | 14.67 | 1.54 | 7.18 | 0.8 | 210 |
B6n | Receptor tyrosine kinase ligand (LERK-3) | 0.30 | 0.12 | 0.12 | 2.40 | 1.65 | 2.3 | 45 |
Heat shock proteins | ||||||||
B7l | Heat shock protein HSP27 | 1.83 | 1.56 | 1.19 | 4.50 | 2.39 | 0.9 | 30 |
B7i | Heat-shock protein 40 | 1.55 | 1.56 | 1.53 | 1.45 | 1.15 | −0.9 | 255 |
B7j | Chaperonin (HSP60) | 0.64 | 0.47 | 0.47 | 1.06 | 1.11 | 0.8 | 45 |
B7m | Heat shock protein (HSP 70) | 0.47 | 0.37 | 0.16 | 0.81 | 0.52 | 1.0 | 60 |
B7k | Heat shock protein hsp86 | 0.31 | 0.17 | 0.19 | 1.76 | 2.41 | 2.1 | 45 |
Adenosine receptors | ||||||||
C1h | A2a adenosine receptor | 0.53 | 0.68 | 0.53 | 0.55 | 0.43 | −0.9 | 225 |
C1i | A1 adenosine receptor | 3.01 | 3.22 | 2.27 | 2.17 | 1.06 | 0.4 | 240 |
C1j | A3 adenosine receptor | 0.56 | 0.47 | 0.37 | 0.71 | 0.50 | −0.3 | 30 |
Inflammatory | ||||||||
F2j | RANTES pro-inflammatory cytokine | 9.30 | 32.49 | 45.30 | 23.54 | 51.80 | −0.7 | 150 |
F6b | Interleukin-6 (IL-6) precursor | 1.19 | 0.39 | 0.43 | 5.73 | 3.07 | 2.0 | 30 |
F6f | Interleukin-10 (IL-10) | 4.16 | 4.64 | 7.42 | 5.02 | 2.59 | 0.6 | 270 |
Transcription factors | ||||||||
D2g | cAMP-responsive element-binding protein | 1.17 | 1.28 | 1.10 | 0.70 | 0.67 | 0.3 | 225 |
B3a | NFκB transcription factor p65 subunit | 0.56 | 0.39 | 0.33 | 0.79 | 0.62 | 0.5 | 45 |
Miscellaneous | ||||||||
A5i | MUC18 glycoprotein | 0.59 | 0.27 | 0.50 | 0.45 | 1.17 | 0.6 | 60 |
C4l | Caspase-9 precursor | 1.50 | 1.07 | 1.27 | 8.36 | 4.76 | 1.7 | 30 |