Fig. 1From: Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)Schematic representation of the pRb/p53/MDM2 network. p53 induces the expression of MDM2; MDM2 binds to p53 and forms an autoregulatory feedback loop (9). In addition, MDM2 interacts with pRB, thus forming a trimeric complex (12,13).Back to article page