Differences in Proteinase K Resistance and Neuronal Deposition of Abnormal Prion Proteins Characterize Bovine Spongiform Encephalopathy (BSE) and Scrapie Strains

Table 1 Incubation times of BSE and scrapie strains and isolates in rodent TSE models

Strain/isolate	Source/host species	Rodent species or breed used for prion propagation	Incubation time (days ± SEM)
Chandler	Mouse scrapie strain	C57BL/6 mice	164 ± 4.7
		CD-1 mice	147 ± 5.1
		Tg20 mice	65 ± 0.7
22A	Mouse scrapie strain	C57BL/6 mice	481 ± 3.4
		VM95 mice	195 ± 1.2
ME7	Mouse scrapie strain	C57BL/6 mice	179 ± 7.9
79A	Mouse scrapie strain	C57BL/6 mice	169 ± 10.9
87V	Mouse scrapie strain	VM95 mice	370 ± 11.3
263K	Hamster scrapie strain	Syrian hamster	83 ± 1.8
Hessen1	Sheep scrapie isolate	C57BL/6 mice	296 ± 7.3
S833	Sheep scrapie isolate	C57BL/6 mice	142 ± 12.3
S540	Sheep scrapie isolate	C57BL/6 mice	442 ± 3.2
BSE-UK	Cattle BSE isolate	C57BL/6 mice^a	202 ± 6.2
		VM95 mice^b	339 ± 3.6
BSE-G	Cattle BSE isolate	C57BL/6 mice^a	197 ± 7.0
		VM95 mice^b	353 ± 12.1

ISSN: 1528-3658