Table 1 The potential of DNA vaccines

Noninfectious/nonreplicating

Potential for insertion into the genome

Proteins produced in native conformation, particularly viral proteins

Potency of immune responses, particularly in larger animals and humans

Physiochemical homogeneity; possibly easier to incorporate several components in a single vaccine

Autoimmunity

Simplified production

Physiochemical stability

Induction of CTLs

Utility of molecular biology