Fig. 3From: Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression Induction of p53 accumulation by AS2 in different tumor cell lines. Cells were cultured on chamber slides, treated with 200 nM AS2 or control oligonucleotide K for 20 hr, and stained for p53 expression using Pab1801. Treatment with AS2 induced strong nuclear p53 accumulation in cells with low basal levels of wild-type p53.Back to article page