Fig. 5
From: Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression
Induction of p53 transcriptional activation function.
Cells stably transfected with the BP100-luciferase reporter were treated with antisense oligonucleotides at indicated concentrations for 20 hr. Luciferase activity/unit protein was determined and the magnitude of induction was shown, compared to cells not treated with oligonucleotides. AS2M4, a 4-bp mismatch control of AS2; K, an unrelated oligonucleotide.