Fig. 7From: Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression Inhibition of DNA synthesis by MDM2 antisense oligonucleotides. Cells were treated with 100 nM of oligonucleotides for 20 hr and labeled for 2 hr with BrdU. Incorporation rate of BrdU was determined by an ELISA assay and normalized to the number of viable cells. H1299 and 10(1) cells are human and mouse cells devoid of p53. LC, lipofectin treatment alone.Back to article page