From: Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression
 |  |  |  | Nuclear p53 Level | |
---|---|---|---|---|---|
Cell Line | Origin | MDM2 Level | p53 | Basal | AS2 Treated |
JEG-3 | Choriocarcinoma | + + + + | wt | + + + + | + + + + |
JAR | Choriocarcinoma | + + + + | wt | + + + + | + + + + |
SJSA | Osteosarcoma | + + + + | wt | − | + + + + |
LS180 | Colon carcinoma | − | wt | − | + + + + |
HT1080 | Fibrosarcoma | + | wt | + | + + + + |
A172 | Glioblastoma | − | wt | − | + + + + |
U87-MG | Glioblastoma | − | wt | + | + + + + |
HepG2 | Hepatocarcinoma | + | wt | + | + + + + |
SLK | Kaposi’s sarcoma | − | ND | + | + + + + |
101 | Kidney tumor | − | wt | + | + + + + |
A549 | Lung tumor | + | wt | + | + + + + |
G361 | Melanoma | + + | wt | + | + + + + |
SK-N-SH | Neuroblastoma | − | wt | − | + + + + |
MCF-7 | Breast carcinoma | + | wt | + | + + + + |
U2OS | Osteosarcoma | + | wt | + + | + + + |
PA-1 | Ovarian teratoma | + | wt/mt | − | + + + + |
Lncap | Prostate carcinoma | − | wt | + | + + + + |
WI-38 | Lung fibroblast | + | wt | − | + + + + |
JeKin | Skin fibroblast | − | wt | + | + + + + |
MDA-MB-231 | Breast carcinoma | + + | mt | + + + + | + + + + |
DLD-1 | Colon carcinoma | + + | mt | + + + + | + + + + |
C33A (HPV−) | Cervical carcinoma | + + | mt | + + + + | + + + + |
Hela (HPV+) | Cervical carcinoma | − | wt | − | − |
Caski (HPV+) | Cervical carcinoma | − | wt | − | − |
H1299 | Lung tumor | − | Null | − | − |
SK-N-MC | Neuroblastoma | — | Null | — | — |