Fig. 1

Schematic map of Mdm2, illustrating functional motifs and protein-interacting domains, as well as potential sites for phosphorylation by DNA-dependent protein kinase (DNA-PK). The N-terminal site (serl7 of human Mdm2) has been shown to be phosphorylated in vitro by DNA-PK. All other DNA-PK sites are based only on sequence predictions. The N terminus harbors binding sites for p53, as well as other proteins (see text). The central region is highly acidic and is capable of binding the ribosomal L5 protein. The C-terminal RING finger has been shown to bind RNA. *, DNA-PK sites; NLS, nuclear localization signal; NES, nuclear export signal.