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Fig. 2 | Molecular Medicine

Fig. 2

From: Role of Macrophage Migration Inhibitory Factor (MIF) in Peripheral Nerve Regeneration: Anti-MIF Antibody Induces Delay of Nerve Regeneration and the Apoptosis of Schwann Cells

Fig. 2

Time-course study on regenerating axons. The numbers of regenerating axons were counted based on positive staining of neurofilaments per field (×400). Anti-MIF antibodies were administered into regenerating rat sciatic nerves using the silicon chamber model as described in “Materials and Methods.” (A) The number of axons in the silicon chamber. A significant difference was found between the anti-MIF antibody-treated and non-immune IgG-treated (control) nerve segments at weeks 2 and 4 after surgery (n = 5) (*p < 0.05). Open bars, non-immune IgG; closed bars, anti-MIF antibody. (B) The number of axons in the distal nerve segment. A significant difference was found between the anti-MIF antibody-treated nerves and the control at week 4 after surgery (n = 5) (*p < 0.05). NS; not significant. Open bars, non-immune IgG; Closed bars, anti-MIF antibody. The values are expressed as mean ± SD.

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Molecular Medicine

ISSN: 1528-3658