Table 1 Complement inhibition strategies and their effects in different models of tissue ischemia/reperfusion
From: The Role of the Complement Cascade in Ischemia/Reperfusion Injury: Implications for Neuroprotection
| Â | Study | Year/Anticomplement Strategy | Model System | Species | Result |
|---|---|---|---|---|---|
Systemic I/R | Â | Â | Â | Â | Â |
Models | Maroko et al. (91) | 1978 CVF | Cardiac ischemia | Dog | Decreased infarct size |
| Â | Maclean et al. (93) | 1978 CVF | Cardiac ischemia | Rat | Decreased infarct size |
| Â | Crawford et al. (92) | 1988 CVF | Cardiac ischemia | Baboon | Decreased infarct size |
| Â | Weisman et al. (62) | 1990 sCR1 | Cardiac ischemia | Rat | Decreased infarct size |
| Â | Hill et al. (4) | 1992 sCR1 | Intestinal ischemia | Rat | Decreased intestinal injury |
| Â | Pemberton et al. (3) | 1993 sCR1 | Skeletal muscle ischemia | Mouse | Increased muscle cell viability and improved circulation |
| Â | Buerke et al. (109) | 1995 C1-INH | Cardiac ischemia | Cat | Improved contractility and vascular function |
| Â | Murohara et al. (110) | 1995 C1-INH, sCR1 | Cardiac ischemia | Rat | Attenuation of neutrophil accumulation and myocardial injury |
| Â | Amsterdam et al. (100) | 1995 C5a MAb | Cardiac ischemia | Pig | Inhibition of neutrophil cytotoxic activity |
| Â | Candinas et al. (96) | 1996 sCR1, CVF | Xenotransplantation/heart | Pig/Rat | Decrease inflammatory response |
| Â | Hopken et al. (102) | 1996 CVF, C5a MAb | Septic shock | Pig | Decreased serum IL-6 bioactivity (75%) |
|  | Weiser et al. (104) | 1996 C3 −/−, C4 −/− | Skeletal muscle ischemia | Mouse | Protection against reperfusion injury |
| Â | Naka et al. (84) | 1997 sCR1 | Isogenic lung transplantation | Rat/Rat | Improved outcomes |
| Â | Lazar et al. (97) | 1998 sCR1 | Cardiac ischemia | Pig | Significant limitation of ischemic damage |
| Â | Vakeva et al. (101) | 1998 C5a MAb | Cardiac ischemia | Rat | Decreased infarct size |
|  | Kilgore et al. (105) | 1998 C6 −/− | Cardiac ischemia | Rabbit | Decreased infarct size; decrease neutrophil influx |
| Â | Fitch et al. (103) | 1999 Human C5 Ab | Cardiopulmonary bypass | Human | Attenuation of postoperative myocardial injury, cognitive deficits, and blood loss |
Cerebral I/R | Â | Â | Â | Â | Â |
Models | Vasthare et al. (140) | 1998 CVF | B CCA occlusion | Rats | Improved cerebral blood flow and outcom |
| Â | Lew et al. (141) | 1999 CVF | ICA autologous clot | Rabbit | No change in infarct volume |
| Â | Huang et al. (15) | 1999 sCR1 | MCA occlusion/reperfusion | Mouse | Inhibition of platelet and neutrophil accumulation; reduced infarct volumes |