Fig. 1
From: Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase
Myocardial infarct size in PARS+/+ and PARS−/− sham control animals and PARS+/+ and PARS−/− animals subjected to IPC after 30 min occlusion of LAD and 24 hr reperfusion. Infarct size is represented as a ratio of weight of the infarct tissue and weight of the area at risk (IF/area at risk). No difference was found between the four groups in area at risk as characterized by a ratio of area at risk and left ventricle (p, 0.05). Ischemic preconditioning caused 35% reduction of infarction size in PARS1 /1 mice when compared with the response in nonpreconditioned animals (p, 0.05). Without preconditioning, PARS2 /2 mice developed a significant reduction in the infarct size after 30 min occlusion than the PARS1 /1 mice (p, 0.05). However, ischemic preconditioning markedly enhanced the infarct size in the PARS2 /2 mice (p, 0.05). Thus, there was no significant difference in infarct size between the preconditioned PARS2 /2 myocardial infarction group and the PARS1 /1 nonpreconditioned group. Data shown as mean 6 SEM; n 5 7–8 determinations per experimental group.