Fig. 9
From: Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase
AAR (A) and infarct size in percent of the AAR (B) or of the left ventricle (C) in preconditioned and nonpre-conditioned rats treated with vehicle or the PARS inhibitor 3-AB before or after IPC. Both 3-AB treatment (3-AB MI) and preconditioning (IPC MI) reduced infarct size in comparison to untreated rats (MI group). The benefit of preconditioning was lost when rats were treated with 3-AB before preconditioning (3-AB IPC MI), and it was not influenced when 3-AB was administered after preconditioning (IPC 3-AB MI). Data are shown as mean 6 SEM. *p, 0.05 versus MI group. †p, 0.05 versus IPC group.