Fig. 4From: Low Levels of p27 in Association With Deregulated p53-pRb Protein Status Enhance Tumor Proliferation and Chromosomal Instability in Non-Small Cell Lung CarcinomasThe p53-p27-pRb network. p53 indirectly (via Waf1) represses cyclin/cdk complexes (15,43) and thus enhances p27 levels (4,5). p27, as an inhibitor of the former complexes, also affects pRb phosphorylation status and S-phase transition (1,42).Back to article page