Low Levels of p27 in Association With Deregulated p53-pRb Protein Status Enhance Tumor Proliferation and Chromosomal Instability in Non-Small Cell Lung Carcinomas

Tsoli, Efthymia; Gorgoulis, Vassilis G.; Zacharatos, Panayotis; Kotsinas, Athanassios; Mariatos, George; Kastrinakis, Nikolaos G.; Kokotas, Stavros; Kanavaros, Panayotis; Asimacopoulos, Panayotis; Bramis, John; Kletsas, Dimitris; Papavassiliou, Athanasios G.; Kittas, Christos

doi:10.1007/BF03402188

Molecular Medicine

Table 1 Summary of p27, Ki-ras, pRb and p53 status, kinetic parameters, ploidy and clinicopathologic features

From: Low Levels of p27 in Association With Deregulated p53-pRb Protein Status Enhance Tumor Proliferation and Chromosomal Instability in Non-Small Cell Lung Carcinomas

Patient	p27 Status (%)	Ki-ras Mutations	pRB Status	p53 Status	PI (%)	AI (%)	GI (%)	Ploidy	Histology	LN	Stage	Survival Status (Months after surgery)
1	25	1	Ab	p	31.1	4.8	6.5	A	AdC	yes	III	3
2	N/A	no	N/A	N/A	NI	NI	NI	NI	SqC	yes	III	21
3	50	no	No	n	28.3	1.6	17.7	A	SqC	no	I	37*
4	8	no	Ab	p	NI	NI	NI	A	ULC	no	I	0
5	30	N/A	No	p	32.8	6.3	5.2	A	AdC	yes	III	12
6	20	N/A	Ab	p	45.6	0.6	76.0	A	SqC	yes	II	35*
7	50	N/A	No	p	27.2	1.2	22.7	A	SqC	yes	II	35*
8	38	N/A	No	p	31.0	1.4	22.1	D	AdC	no	I	34*
9	43	no	Ab	p	30.3	2.0	15.2	D	AdC	no	I	35*
10	20	no	No	p	40.6	1.8	22.6	A	ULC	yes	II	9
11	28	no	No	p	36.0	0.7	51.4	A	SqC	no	I	34*
12	32	N/A	Ab	p	29.5	0.9	32.8	A	SqC	no	I	35*
13	38	no	No	p	32.8	NI	NI	D	SqC	yes	III	8
14	27	no	Ab	p	38.5	1.3	29.6	A	SqC	yes	III	8
15	19	2	Ab	p	40.6	1.1	36.9	A	SqC	no	I	34*
16	68	no	No	p	4.6	0.8	5.8	D	AdC	no	I	7
17	28	no	No	p	27.3	1.2	22.8	NI	SqC	no	II	34*
18	19	no	No	p	43.6	4.8	9.1	D	SqC	yes	II	11
19	28	no	No	n	NI	10.6	NI	D	AdC	no	I	34*
20	46	no	No	n	24.6	3.5	7.0	D	SqC	no	I	34*
21	30	no	No	n	34.5	NI	NI	D	SqC	yes	III	1
22	44	1	No	n	46.6	1.5	31.1	D	AdC	no	I	34*
23	50	no	Ab	n	26.7	2.6	10.3	D	AdC	yes	II	18
24	58	2	No	p	26.7	0.8	33.4	NI	SqC	no	I	N/A
25	42	no	Ab	n	21.3	1.4	15.2	D	AdC	no	I	33*
26	36	no	No	p	29.2	0.1	292.0	A	AdC	yes	II	17
27	68	no	Ab	n	13.3	3.5	3.8	NI	AdC	yes	II	14
28	25	no	Ab	p	40.9	1.5	27.3	A	SqC	no	I	33*
29	21	no	Ab	p	43.4	2.7	16.1	A	ULC	yes	III	0
30	38	1	No	n	28.8	5.2	5.5	D	ULC	no	I	32*
31	53	no	No	n	21.2	3.0	7.1	D	AdC	no	I	10
32	47	N/A	No	n	26.4	0.7	37.7	A	AdC	yes	III	30*
33	20	N/A	Ab	n	40.7	0.8	50.9	A	SqC	no	I	14
34	38	N/A	Ab	n	34.7	0.5	69.4	D	AdC	no	I	32*
35	31	N/A	Ab	p	29.2	0.8	36.5	A	AdC	yes	II	17
36	29	N/A	No	n	28.8	99.0	NI	A	AdC	yes	III	10
37	60	no	No	n	28.9	3.2	9.0	A	AdC	yes	II	12
38	32	N/A	No	p	39.3	3.0	13.1	A	SqC	yes	III	30*
39	8	no	No	n	54.0	0.9	60	D	SqC	yes	III	9
40	33	N/A	No	n	31.0	NI	NI	A	ULC	no	I	18
41	31	N/A	No	n	38.0	0.5	76.0	A	SqC	no	I	30*
42	15	no	No	p	43.8	0.6	73.0	A	SqC	yes	III	30*
43	42	no	No	n	21.4	3.5	6.1	A	AdC	yes	II	30*
44	43	1	No	n	22.3	0.7	31.9	A	AdC	yes	III	14
45	21	1	No	n	32.9	8.9	3.7	D	AdC	yes	II	27
46	22	no	No	n	NI	NI	NI	D	AdC	no	I	29*
47	8	no	Ab	p	54.4	0.5	108.8	A	SqC	no	I	25
48	19	no	Ab	p	44.0	0.5	88.0	D	SqC	no	III	14
49	25	no	Ab	n	36.9	NI	NI	D	AdC	no	I	29*
50	54	2	No	n	18.1	1.4	12.9	D	AdC	yes	II	27
51	52	no	No	n	20.0	2.9	6.9	D	AdC	yes	II	15
52	30	N/A	No	p	39.0	0.6	65.0	A	SqC	no	III	29*
53	25	no	Ab	p	51.2	2.6	19.7	A	SqC	yes	III	15
54	31	1	No	n	32.2	3.1	10.4	NI	SqC	no	I	28*
55	25	no	Ab	p	43.3	0.8	54.1	A	AdC	yes	II	10
56	30	1	Ab	p	47.3	0.4	118.3	A	SqC	yes	II	11
57	32	no	Ab	p	40.0	1.8	22.2	A	SqC	yes	III	8
58	25	no	Ab	p	46.0	0.6	76.7	A	AdC	yes	II	26*
59	33	1	No	p	30.4	NI	NI	A	AdC	no	I	25
60	20	1	Ab	p	38.6	1.0	38.6	A	AdC	yes	III	23
61	40	2	No	p	24.5	1.1	22.3	D	AdC	yes	III	26*
62	25	N/A	No	n	41.4	1.4	29.6	A	SqC	no	I	13
63	N/A	no	Ab	p	50.6	1.0	50.6	A	AdC	no	III	25*
64	33	no	Ab	p	39.3	1.6	24.6	D	AdC	no	I	25*
65	10	no	Ab	p	70.4	0.7	100.6	A	SqC	yes	II	22
66	30	2	No	n	33.3	2.3	14.5	A	SqC	yes	II	3
67	51	no	No	p	20.2	0.6	33.7	D	AdC	no	I	24*
68	8	no	No	p	59.1	2.1	28.1	A	SqC	yes	II	21
69	30	no	No	p	NI	0.9	NI	A	AdC	yes	II	23

Abbreviations: N/A, data not available; no mutations; 1, mutation at codon 12; 2, mutation at codon 13; NI, non-informative; Ab, aberrant expression; No, normal expression; p, positive expression; n, negative expression; PI, proliferation index; AI, apoptotic index; GI, growth index; A, aneuploid; D, diploid; SqC, squamous cell carcinoma; AdC, adenocarcinoma; ULC, undifferentiated large cell carcinoma; LN, lymph node invasion; *, patient still alive.

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ISSN: 1528-3658

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