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Fig. 8 | Molecular Medicine

Fig. 8

From: p21WAF1 Prevents Down-modulation of the Apoptotic Inhibitor Protein c-IAP1 and Inhibits Leukemic Apoptosis

Fig. 8

Heightened expression of c-IAP1 in myeloid leukemias. 40 µg protein extracts of untreated (#1,2,3,4,5,6,8,9,10) or relapsed (#7 and 11) myeloid leukemias or of CD34+ hematopoietic progenitor cells exposed for 3–12 days to granulocyte colony stimulating factor (G-CSF), interleukin-3 (IL-3) and stem cell factor (SCF) were blotted for c-IAP1 expression. A parallel gel was blotted for p21WAF1 expression. The leukemias consisted of >90% blasts. Equal loading was evident on total protein staining of membrane. Blotting for (Stat3) highlights the presence of protein in CD34 samples.

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Molecular Medicine

ISSN: 1528-3658