Skip to main content

Table 2 Gene expression abundance profiles between normal and poorly differentiated serous papillary adenocarcinoma (PD-SPA) of the ovary

From: Changes in Tumorigenesis- and Angiogenesis-related Gene Transcript Abundance Profiles in Ovarian Cancer Detected by Tailored High Density cDNA Arrays

Gene

Gene Card ID

Accession

Normalb

PD-SPAc

P-Valued

ANGIOGENIC FACTORS, RECEPTORS AND MEDIATORS

ANGIOPOLETLN-1

ANGPT1

homea

0.40

0.91

0.005

MACROPHAGE METALLOELASTASE

MMP12

N41372

−0.13

0.76

0.010

PLASMINOGEN ACTIVATOR INHIBITOR-1

PAI1

N73364

0.22

0.80

0.019

soluble VEGF RECEPTOR 1

(sflt)

homea

0.32

0.89

0.003

THROMBOSPONDIN 1

THBS1

AA404574

0.37

0.73

0.047

THROMBOSPONDIN 4

THBS4

H27672

0.96

1.86

0.024

TRANSFORMING GROWTH FACTOR BETA 3

TGFB3

AA460527

0.04

0.64

0.028

VEGF RECEPTOR 1

FLT1

T52673

0.69

1.09

0.009

VEGF A

VEGF

homea

0.19

0.89

0.034

CELL ADHESION, RECOGNITION AND CYTOSKELETON

CADHERIN-11 (OB-)

CDH11

AA137109

0.34

0.93

0.036

CADHERIN-6, (K-)

CDH6

AA434602

2.62

1.74*

0.038

COFILIN

CFL1

N41410

0.78

1.70

0.025

HLA CLASS I ANTIGEN (B-12)

HLA-C

T58784

1.57

2.77

0.000

HLA CLASS II ANTIGEN, DR-1 BETA

HLA-DRB1

AA033653

0.31

1.15

0.008

MOESIN

MSN

AA170514

−0.01

0.75

0.039

MUCIN 1

MUC1

AA292565

0.69

1.37

0.027

GROWTH FACTORS, CYTOKINES, HORMONES AND RECEPTORS

   

CHORIOGONADOTROPIN BETA CHAIN

CGB

N42013

−0.01

0.37

0.040

ENDOTHELIN-1 RECEPTOR

EDNRA

N57394

2.33

0.88*

0.034

GM-COLONY-STIMULATING FACTOR RECEPTOR

CSF2RA

R65621

0.42

0.83

0.048

MACROPHAGE INFLAMMATORY PROTEIN 1-BETA

SCYA4

H62985

0.36

0.90

0.031

MAST/STEM CELL GROWTH FACTOR RECEPTOR

KIT

H96451

−0.52

0.60

0.002

TRANSFERRIN RECEPTOR

TFRC

H81477

0.19

0.90

0.026

TYROSINE-PROTEIN KINASE RECEPTOR RON

MST1R

AA129088

0.10

1.12

0.001

VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2

VIPR2

AA495891

−0.10

0.64

0.019

INTRACELLULAR SIGNALLING, TRANSCRIPTION FACTORS AND NUCLEAR RECEPTORS

BAD PROTEIN

BAD

AA461579

0.29

0.98

0.044

MYB-RELATED PROTEIN B (B-myb)

MYBL2

AA100862

0.42

0.89

0.007

NEURON-RESTRICTIVE SILENCER FACTOR

REST

AA489735

0.21

1.12

0.021

NEUTROPHIL CYTOSOL FACTOR 1 (P47-PHOX)

NCF1

T58661

0.79

1.50

0.033

ENZYMES AND OTHERS

     

CYTOCHROME C

CYC1

N29104

0.41

1.00

0.019

GLUCOSE TRANSPORTER TYPE 1

SLC2A1

H79697

0.45

0.89

0.046

GLUTATHIONE S-TRANSFERASE P

GSTP1

AA173289

0.87

1.43

0.031

NADH-UBIQUINONE DEHYDROGENASE

NDUFV2

W00360

0.50

1.06

0.035

SUPEROXIDE DISMUTASE (Mn-)

SOD2

R15738

0.22

0.97

0.038

  1. ahome = clones derived and characterized in previous studies in our laboratory.
  2. bNORMAL = mean ln(signal intensity) of 5 samples of normal ovary.
  3. cPD-SPA = mean ln(signal intensity) of 4 samples of poorly-differentiated serous papillary adenocarcinoma.
  4. dP-VALUE is from unpaired t-test between NORMAL and PD-SPA.
  5. *Gene transcript abundance of these genes was lower in PD-SPA than NORMAL ovarian samples.
  6. All other genes listed showed higher transcript abundance in the PD-SPA samples.
Back to article page

Molecular Medicine

ISSN: 1528-3658