Fig. 6

Plasma/lumen ratio of FD4, an indicator of intestinal epithelial permeability, in the intestine of zymosan-treated mice. Epithelial permeability significantly increased in zymosan-treated iNOS WT mice. Zymosan-treated iNOS KO mice and iNOS WT mice treated with NAC or 3-AB showed a significant reduction in the increase in permeability. Each value is the mean ± standard error of the mean (SEM) for n = 10 animals. *p < 0.01 vs. sham; °p < 0.01 vs. zymosan-treated iNOS WT. iNOS, inducible nitric oxide synthase; WT, wild type; KO, mice lacking iNOS; NAC, n-acetylcysteine.