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Fig. 1 | Molecular Medicine

Fig. 1

From: Common Germinal-Center B-Cell Origin of the Malignant Cells in Two Composite Lymphomas, Involving Classical Hodgkin’s Disease and Either Follicular Lymphoma or B-CLL

Fig. 1

Histology and immunohistology of the two composite lymphomas. (A) to (D) case 1; (E) to (H) case 2. (A) Mesenteric lymph node infiltrated by follicular lymphoma showing numerous neoplastic follicles. (Hematoxilin & eosin staining, 0.5 ×.) (B) Combination of FL and HD. Infiltrates of the B-cell NHL on the top, bottom and right side of the picture. Mainly in the middle and on the left top an infiltrate of HD composed of small lymphocytes, histiocytes, epitheloid cells and a Hodgkin cell. (Hematoxilin & eosin staining, 20×.) (C) Infiltrate of HD showing a Reed-Sternberg cell in the middle of the picture. The other part of the hilar lymph node (not shown here) is infiltrated by a FL. (Hematoxilin & eosin staining, 40×.) (D) HRS cells of the combination of HD and FL showing a positive immunostaining with CD15, 40×. (E) HRS cells on a background rich in lymphocytes and histiocytes, hematoxilin & eosin staining, 150×. (F) Diffuse areas with CD20-positive B-CLL cells surrounding small islands with HRS cells (180×). (G) Part of the HRS cells express CD15 (120×). (H) CD3 staining. The HD islands contain mainly CD3-positive T cells, with formation of rosettes around HRS cells (120×).

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Molecular Medicine

ISSN: 1528-3658