Fig. 2
Genealogical trees of somatic mutation patterns and scenario for the generation of composite lymphomas. (A) Genealogical tree showing the relationship between the HRS cell clone, the FL and the presumptive premalignant B cell (BC12) belonging to the same clone in patient 1. The tree is based on the VH sequences. A similar and compatible pattern is seen for the clonal Vκ gene rearrangements of the cells (not shown). “N” denotes the presumptive naive founder B cell of the clone, “X” and “Y” denote hypothetical intermediates in the clonal evolution of the subclones. The number of somatic mutations (mut.) in the development of the clone members is given. For the FL, only shared mutations are considered. (B) Genealogical tree showing the relationship between the HRS cell and B-CLL clone in patient 2. The tree is based on the VH and Vλ sequences. “N” denotes the presumptive naive founder B cell of the clone, “X” denotes the hypothetical shared precursor of the lymphoma clones. The number of somatic mutations (mut.) in the development of the clone members is given. (C) Scenario for composite lymphoma generation (11). Horizontal lines in the cells indicate rearranged Ig genes, vertical lines represent somatic mutations.