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Table 3 V gene sequence and mutation analysis of Ig gene rearrangements from HRS and B-NHL cells of two composite lymphomas

From: Common Germinal-Center B-Cell Origin of the Malignant Cells in Two Composite Lymphomas, Involving Classical Hodgkin’s Disease and Either Follicular Lymphoma or B-CLL

Case

Source of Cells

V Gene (V Family)

Potentially Functional

Mutation Frequency(%)

Lymphomas Clonally Related

Intraclonal Diversity

Samples With Sequence Variation*

1

Hodgkin’s disease

V3-23 (VH3)

Yes

11.7

 

No

−/19

  

A27 (Vκ3)

Yes

9.1

 

No

−/5

     

Yes

  
 

Follicular lymphoma

V3-23 (VH3)

Yes

10.3#

 

Yes

14/14

  

A27 (Vκ3)

Yes

7.4#

 

Yes

10/11

2

Hodgkin’s disease

V1-2 (VH1)

Yes

2.1

 

No

−/6

  

V2-14 (Vλ2)

Yes

1.5

 

No

−/10

     

Yes

  
 

B-CLL

V1-2 (VH1)

Yes

2.3

 

No

−/4

  

V2-14 (Vλ2)

Yes

0.8

 

No

−/4

  1. *Number of variations per total number. The dash indicates that all sequences are identical.
  2. #Considering only shared mutations.
  3. V gene sequences have been submitted to the EMBL data library (accession numbers AJ 409167-AJ409197).
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Molecular Medicine

ISSN: 1528-3658