Fig. 5

Lung histology of conducting airways and parenchyma. Sections of formalin-fixed lung tissue from control mice (A and B), and from mice intranasally challenged with B. malayi γ-GT (C, D, E, and F). V, vascular compartaient; b, bronchiolus. C and E, Dense perivascular infiltration with leukocytes is shown after the intranasal challenge with γ-GT. D and C severe peribronchial inflammation. Sections A and E were stained with Red Sirius F3B to visualize eosinophils, clearly visible as red spots in panel E. The airways epithelium was enlarged compared to vehicle-sensitized mice, which did not show any histological changes (B). Sections B, C, D, and F were stained with hematoxylin. A, B, D ×320; C ×220 E, and F ×520.