From: Role of Macrophage Oxidative Burst in the Action of Anthrax Lethal Toxin
Mice Surviving (n = 8) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Toxin Dose | Antioxidantd | Day 0 | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 14e |
High Dosea | None | 8 | 3 | 1 | 0 | — | — | — | — | 0 |
NAC | 8 | 7 | 5 | 3 | 3 | 2 | 1 | 0 | 0 | |
Ascorbate | 8 | 6 | 4 | 2 | 1 | 0 | — | — | 0 | |
Mepacrine | 8 | 6 | 5 | 4 | 2 | 1 | 0 | — | 0 | |
Medium Doseb | None | 8 | 6 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
NAC | 8 | 8 | 7 | 6 | 4 | 3 | 3 | 3 | 3 | |
Ascorbate | 8 | 5 | 4 | 2 | 2 | 1 | 0 | — | 0 | |
Mepacrine | 8 | 7 | 6 | 4 | 3 | 3 | 3 | 3 | 3 | |
Low dosec | None | 8 | 7 | 6 | 4 | 3 | 3 | 2 | 2 | 2 |
NAC | 8 | 8 | 7 | 6 | 6 | 6 | 6 | 6 | 6 | |
Ascorbate | 8 | 6 | 5 | 5 | 4 | 4 | 3 | 3 | 3 | |
Mepacrine | 8 | 6 | 6 | 5 | 5 | 5 | 5 | 5 | 5 |