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Table 3 Effect of antioxidants on lethal toxin-induced mortality of mice

From: Role of Macrophage Oxidative Burst in the Action of Anthrax Lethal Toxin

  

Mice Surviving (n = 8)

Toxin Dose

Antioxidantd

Day 0

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Day 7

Day 14e

High Dosea

None

8

3

1

0

—

—

—

—

0

 

NAC

8

7

5

3

3

2

1

0

0

 

Ascorbate

8

6

4

2

1

0

—

—

0

 

Mepacrine

8

6

5

4

2

1

0

—

0

Medium Doseb

None

8

6

3

1

1

1

1

1

1

 

NAC

8

8

7

6

4

3

3

3

3

 

Ascorbate

8

5

4

2

2

1

0

—

0

 

Mepacrine

8

7

6

4

3

3

3

3

3

Low dosec

None

8

7

6

4

3

3

2

2

2

 

NAC

8

8

7

6

6

6

6

6

6

 

Ascorbate

8

6

5

5

4

4

3

3

3

 

Mepacrine

8

6

6

5

5

5

5

5

5

  1. Anthrax lethal toxin was administered to anesthetized animals in 300 µl sterile PBS via the tail vein. Antioxidants or mock were administered to animals in 200 µl sterile PBS at the same time as toxin at a second tail vein site.
  2. aLeTx = 100 µg PA + 20 µg LF per animal.
  3. bLeTx = 50 µg PA + 10 µg LF per animal.
  4. cLeTx = 50 µg PA + 5 µg LF per animal.
  5. dAntioxidant dose = 800 mg per animal.
  6. eNo deaths alter day 14.
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Molecular Medicine

ISSN: 1528-3658