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Table 1 Comparison of the Term and Premature Neonatal Immune System

From: Neonatal intestinal dysbiosis in necrotizing enterocolitis

Term Preterm
↓ Physical barriers ↓↓↓ Physical barriers
↑ Effectiveness of immune cells to target pathogens ↓ Number of monocytes and neutrophils
↓ Overall ability to produce cytokines
↓ T cell activation
↓ Number of natural killer cells
↓ Bactericidal/permability-increasing protein ↓↓ Bactericidal/permability-increasing protein
↓ Passive Immunity (level of IgG depends on transplacental transfer and thus increases with gestation age)
  1. ↑ indicates increased; ↓ indicates decreased