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Fig. 2 | Molecular Medicine

Fig. 2

From: Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

Fig. 2

Ethyl pyruvate specifically inhibits the NLRP3 inflammasome activation. For Salmonella infection, unprimed macrophages were infected with wild-type S. typhimurium and the supernatant samples were collected 1 h after infection. For the AIM2 inflammasome activation, macrophages were transfected with DNA using Lipofectamine 2000 and the supernatant samples were collected 6 h after transfection. a Pro-caspase1, caspase1 and HMGB1 release were assessed by Western-blot. b Supernatant levels of HMGB1were determined by ELISA. Results are means ± SEM (n = 3). *p < 0.05; **p < 0.01; ***p < 0.001

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Molecular Medicine

ISSN: 1528-3658