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Fig. 3 | Molecular Medicine

Fig. 3

From: Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

Fig. 3

Metformin attenuated particle-induced mouse calvarial osteolysis without changing the blood glucose level. a Three-dimensional images from micro-CT scans of mouse calvaria, showing evidence of resorption pits along the suture lines in mice in which UHMWPE particles were implanted in comparison with representative images from the metformin- and ALN-treated groups. b ROI selected for quantitative analysis of BMD (c), BMC (d), and BV/TV (e) in each group. f Changes in body weight after operation at days 0, 7 and 14. g Comparison of blood glucose levels between groups ***P < 0.001; **P < 0.01; *P < 0.05; NS, not significant, P > 0.05

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Molecular Medicine

ISSN: 1528-3658