Fig. 1
From: Neuroimmune semaphorins as costimulatory molecules and beyond
Sema3A in DC – T cell crosstalk: a Sema3A inhibits T cell activation. Low constitutive levels of Sema3A on DC are upregulated with cell activation. DC surface-expressed and soluble Sema3A inhibit T cell proliferation presumably acting through NRP-1. b Sema3A inhibits DC activation and chemotaxis. Inducible T cell-expressed and soluble Sema3A use NRP-1 and NRP-2 as ligand-binding receptors and NRP-associated Plexin A1 and A2 as signaling receptors to regulate DC activation and chemotaxis