Fig. 4
From: Neuroimmune semaphorins as costimulatory molecules and beyond
Distinct receptor-dependent effects of T cell-expressed Sema4D on DC functions. a Sema4D costimulates T cells. Sema4D serves as an indirect costimulatory molecule for T cell activation. Sema4D on T cells stimulates DC to accelerate their activation and maturation. Stimulated DC, in their turn, enhance T cell activation. The main receptor for such Sema4D action is believed to be CD72. b Sema4D costimulates DC. T cell-expressing and soluble Sema4D ligation of DC-expressing Plexin B1 and B2 receptors stimulates DC proinflammatory cytokine production and migration