Fig. 6
From: Neuroimmune semaphorins as costimulatory molecules and beyond
T cell inducibly expressed Sema7A has distinct receptor-dependent effects on DC and macrophages. a Sema7A in T cell-DC interaction. Indirect T cell stimulation by T cell expressed Sema7A ligation of Plexin C1 on DC. b Sema7A in T cell-macrophage interaction. Inflammatory macrophages get activated and stimulated for pro-inflammatory cytokine secretion by Sema7A ligation of α1β1 integrin