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Fig. 5 | Molecular Medicine

Fig. 5

From: Targeting DEC-205−DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis

Fig. 5

Potential mechanism of action of a αDEC-205 and b αDCIR2 fusion mAbs. The fusion mAb consist of an antibody against either receptor, with an antigen fused to the constant region. Both antibodies will target receptors on the surface of the DC. Once bound to DC, the fusion mAb delivers the antigen. This antigen delivery leads to anergization or deletion of pathogenic T cells, expansion of thymus derived Tregs, or induction of peripherally derived Tregs. The dominant mechanism of αDEC-205 fusion mAb is induction of peripherally derived Tregs, whereas the dominant mechanism of αDCIR2 fusion mAb is expansion of thymus derived Tregs

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Molecular Medicine

ISSN: 1528-3658