Genome-wide meta-analysis identifies novel loci associated with parathyroid hormone level

Table 3 Associations of top single nucleotide polymorphisms(P < 5 × 10⁻⁶) with PTH concentrations among females

SNP	Chr	Position	Nearest Gene	Effect Allele	Other Allele	EAF Korcula	EAF Vis	EAF Split	GnomAD EAF	β	SE	P value
rs77178854	2	116,496,539	DPP10	C	G	0.98	0.97	0.99	0.98	0.82	0.14	2.21×10⁻⁹
rs1890709	14	49,101,833	LINC00648	A	G	0.38	0.30	0.33	0.31	0.20	0.04	7.12×10⁻⁸
rs16981087	20	19,739,954	SLC24A3	G	C	0.80	0.78	0.77	0.81	0.22	0.04	6.99×10⁻⁷
rs661171	11	110,016,519	ZC3H12C	G	T	0.74	0.70	0.71	0.70	0.20	0.04	8.94×10⁻⁷
rs74629672	20	39,105,870	MAFB	T	A	0.95	0.94	0.94	0.96	0.43	0.09	1.68×10⁻⁶
rs1349573	14	41,403,160	LOC644919	G	A	0.05	0.05	0.06	0.03	0.45	0.10	1.94×10⁻⁶
rs3866634	16	86,567,929	MTHFSD	G	A	0.93	0.92	0.93	0.91	0.32	0.07	2.14×10⁻⁶
rs7997888	13	102,759,325	FGF14	A	G	0.04	0.04	0.04	0.15	0.49	0.10	2.19×10⁻⁶
rs5024438	15	33,077,401	FMN1	G	A	0.72	0.70	0.79	*	0.23	0.05	2.76×10⁻⁶
rs77796218	11	44,580,581	CD82	C	T	0.97	0.96	0.97	0.98	0.49	0.10	2.84×10⁻⁶
rs13406545	2	201,792,123	ORC2	T	A	0.15	0.19	0.18	0.23	0.21	0.05	4.54×10⁻⁶
rs2588129	8	17,462,468	PDGFRL	A	G	0.04	0.02	0.02	0.11	0.54	0.12	4.57×10⁻⁶

Top SNPs were defined as the SNP with lowest P value within a 500 kb window
Chr: chromosome; EAF: effect allele frequency; GnomAD EAF: effect allele frequency from Genome Aggregation Database; β: effect size; SE: standard error
*variants without frequency information in Genome Aggregation Database

ISSN: 1528-3658