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Fig. 1 | Molecular Medicine

Fig. 1

From: Microarray analysis of human keratinocytes from different anatomic sites reveals site-specific immune signaling and responses to human papillomavirus type 16 transfection

Fig. 1

Immune gene mRNA repertoires of stratified human keratinocytes from different anatomical sites vary significantly. Results are for SHKs grown in organotypic cultures from a pool of 3–5 individuals and represent 3 independent samples of each of the mucosal sites shown (baseline and HPV infected). Data were log transformed, and normalized to the median. Eighty one “immunologic genes” are shown, and a principle component analysis (PCA) performed (dots = genes; lines with arrows = tissue types; axis 3 PCA). Tissue types were separated (PC1, PC2, and PC3), to demonstrate differential genetic expression patterns for these genes. Heat maps and the PCA for SHKs from each site are shown for resting (a, d), HPV16 transfected (b, e), and HPV16− or HPV16+ keratinocytes from all sites separately grouped together (c, f)

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Molecular Medicine

ISSN: 1528-3658