Table 1 Cohort analyses
Chemical | RRMS median (IQR) | HC median (IQR) | 95% CI for difference (RRMS-HC) in medians | P value |
|---|---|---|---|---|
For 25OHD and PTH, n = 49 for RRMS and 30 for HC. For all other analytes below, n = 38 for RRMS and n = 25 for HC | ||||
 Winter 25OHD | 58 (40–89) | 43 (36–71) | -3 to 32 | 0.09 |
 Summer 25OHD | 87 (70–108)*** | 81 (70–92)*** | −6 to 18 | 0.4 |
 Winter PTH | 4.5 (3.7–6.0) | 5.8 (4.1–6.6) | −1.6 to −0.3 | 0.02 |
 Summer PTH | 4.7 (3.9–5.7) | 5.0 (4.0–6.0) | − 1.5 to 0.5 | 0.2 |
 Winter iFGF | 43 (36–56) | 41 (35–49) | −5 to 8 | 0.14 |
 Summer iFGF | 46 (40–60) | 47 (38–52) | −6 to 6 | 0.3 |
 Winter FGFc | 95 (76–136) | 85 (73–112) | − 12 to 38 | 0.08 |
 Summer FGFc | 93 (77–114) | 90 (72–124) | − 15 to 18 | 0.3 |
 Winter Klotho | 682 (517–817) | 677 (553–964) | − 182 to 134 | 0.6 |
 Summer Klotho | 588 (491–743) | 732 (571–976) | − 257 to 16 | 0.08 |
 Winter Ferritin | 103 (58–214) | 73 (24–170) | −34 to 75 | 0.2 |
 Summer Ferritin | 98 (44–185) | 90 (35–148) | −32 to 67 | 0.5 |
 Winter 125(OH)2D | 148 (116–181) | 139 (121–155) | −19 to 25 | 0.4 |
 Summer 125(OH)2D | 168 (133–201)+ | 176 (147–204)** | −27 to 27 | 0.7 |
Restricted to subjects who provided both a winter and summer specimen, For all analytes below n = 38 for RRMS and n = 23 for HC | ||||
 Winter 25OHD | 59 (38–91) | 47 (37–79) | −17 to 32 | 0.4 |
 Summer 25OHD | 87 (70–108)** | 81 (70–92)** | −6 to 18 | 0.4 |
 Winter PTH | 4.5 (3.8–6.1) | 5.8 (4.0–6.6) | −1.7 to 0.3 | 0.09 |
 Summer PTH | 4.7 (3.9–5.7) | 5.0 (4.0–6.0) | −1.5 to 0.5 | 0.3 |
 Winter iFGF | 45 (36–59) | 45 (35–50) | −6 to 9 | 0.3 |
 Summer iFGF | 46 (40–60) | 49 (40–52) | −6 to 5 | 0.4 |
 Winter FGFc | 93 (77–134) | 96 (76–123) | − 23 to 24 | 0.4 |
 Summer FGFc | 93 (77–114) | 90 (75–134) | − 15 to 17 | 0.5 |
 Winter Klotho | 681 (523–749) | 677 (569–1034) | − 154 to 104 | 0.5 |
 Summer Klotho | 588 (491–743) | 725 (563–984) | − 231 to 27 | 0.1 |
 Winter Ferritin | 108 (60–224) | 62 (21–153) | −4 to 87 | 0.06 |
 Summer Ferritin | 98 (44–188) | 89 (32–134) | −25 to 67 | 0.4 |
 Winter 125(OH)2D | 150 (114–193) | 148 (126–160) | −16 to 31 | 0.5 |
 Summer 125(OH)2D | 168 (133–201)++ | 177 (145–204)* | −27 to 27 | 0.7 |