Fig. 6

Deficiency of B-1a cells exaggerates lung injury during sepsis. a After 20 h of CLP induced in WT and CD19^−/− mice, lung tissues were harvested and stained with H&E. The slides were observed under light microscopy at × 100 original magnification in a blinded fashion. Representative images for each group are shown. Scale bar, 100 μm. b Histological injury scores of the lungs in WT and CD19^−/− mice were quantified as described in Materials and Methods. Data obtained from three independent experiments are expressed as means ± SE (n = 6 mice/group) and compared by one-way ANOVA and SNK method (^*p < 0.05 vs. shams; ^#p < 0.05 vs. WT CLP mice). CLP, cecal ligation and puncture; H&E, hematoxylin and eosin