Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study

Table 3 Combined results of gene set enrichment analysis from MAGENTA, PASCAL and DEPICT. Pathways are pooled from several repositories which are enlisted with data base. P values from PASCAL, DEPICT and MAGENTA are corrected for multiple testing

		PASCAL	DEPICT	MAGENTA
Data base	Pathway	P value	P value	P value	*Combined P value
KEGG	Allograft rejection	0.083	0.001	0.005	5.62E-04
KEGG	Autoimmune thyroid disease	0.043	0.001	0.022	9.30E-04
KEGG	Glycosaminoglycan biosynthesis keratan sulfate	0.008	0.171	0.036	9.89E-03
REACTOME	Platelet aggregation plug formation	0.044	0.952	0.005	2.28E-02
REACTOME	EGFR downregulation	0.776	0.951	0.003	2.45E-02
REACTOME	Integrin cell surface interactions	0.16	0.396	0.011	4.51E-02
KEGG	Dorso ventral axis formation	0.151	0.233	0.022	4.78E-02
REACTOME	P130CAS linkage to MAPK signaling for integrins	0.035	0.988	0.032	4.85E-02

*Pooled p values are combined using empirical Brown’s method assuming dependency across test hypotheses

ISSN: 1528-3658