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Fig. 6 | Molecular Medicine

Fig. 6

From: Overexpression of miR-21-5p promotes proliferation and invasion of colon adenocarcinoma cells through targeting CHL1

Fig. 6

MiR-21-5p inhibited the expression of CHL1. a The heat map showed that the expression of CHL1 in COAD tissues was lower than that in normal tissues. b TargetScan predicted that there was a binding site for miR-21-5p in the 3’UTR of CHL1. The result of dual-luciferase reporter assay showed that the luciferase activity in miR-21-5p mimics and CHL1 3’UTR-wt co-combination group was lower than that in NC mimics and CHL1 3’UTR-wt co-combination group. In the meantime, there was no significant difference between miR-21-5p mimics and CHL1 3’UTR-mut co-combination group NC mimics and CHL1 3’UTR-mut co-combination group. c, d CHL1 expression in miR-21-5p mimics group was much lower than that in NC mimics group, while that in miR-21-5p inhibitor group was higher than that in NC inhibitor group. **P < 0.01, ***P < 0.001, compared with NC mimics group, &&P < 0.01, compared with NC inhibitor group

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Molecular Medicine

ISSN: 1528-3658