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Fig. 7 | Molecular Medicine

Fig. 7

From: Overexpression of miR-21-5p promotes proliferation and invasion of colon adenocarcinoma cells through targeting CHL1

Fig. 7

CHL1 inhibited COAD cells development. a Colony formation assay indicated that CHL1 suppressed COAD cells growth. b MTT assay revealed that overexpression of CHL1 inhibited cell viability, while knockdown of CHL1 enhanced the proliferation ability of COAD cells. c, d The result of flow cytometry suggested that CHL1 arrested cell cycle in G0/G1 phase, while deletion of CHL1 increased cells in S phase. e, f Transwell assay was performed to detect invasion ability. The cell number in pcDNA3.1 CHL1 group was increased, while that in CHL1 siRNA group was decreased compared with control group. The scale bar was 50 μm. *P < 0.05, **P < 0.01, compared with NC group. #P < 0.05, ##P < 0.01, compared with CHL1 siRNA group

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Molecular Medicine

ISSN: 1528-3658