Fig. 8

MiR-21-5p promoted COAD tumor growth in vivo through inhibiting CHL1 expression. a-c The volume and weight of tumors in miR-21-5p inhibitor group were much lower than that in NC inhibitor group, while that in CHL1 siRNA group was higher than that in siRNA NC group. ^**P < 0.01, compared with NC inhibitor group, ^&&P < 0.01, compared with siRNA NC group. d, e CHL1 expression in miR-21-5p inhibitor group was much higher than that in NC inhibitor group, while that in CHL1 siRNA group was lower than that in siRNA group. Meanwhile, there was no significant difference between NC inhibitor group, siRNA NC group and miR-21-5p inhibitor+CHL1 siRNA co-combination group. ^**P < 0.01, compared with NC inhibitor group, ^##P < 0.01, compared with siRNA NC group. f The expression of miR-21-5p was down-regulated by miR-21-5p inhibitor in vivo evaluated by qRT-PCR. ^**P < 0.01, compared with NC inhibitor group, ^##P < 0.01, compared with siRNA NC group