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Table 1 Baseline ventricular function in Langendorff hearts

From: Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury

Groups

LVDP mmHg

LV-dP/dt max mmHg/s

LV-dP/dt min mmHg/s

CF ml/min

Heart rate bmp

WT

80 ± 10

2563 ± 337

2773 ± 437

3.6 ± 0.3

392 ± 38

MHC-HDAC4

106 ± 15

2757 ± 417

2843 ± 2521

2.8 ± 0.4

368 ± 28

TSA + WT

115 ± 6

3126 ± 168

3066 ± 82

3.8 ± 0.5

349 ± 29

TSA+ α-MHC-HDAC4

94 ± 8

3394 ± 258

3237 ± 180

3.6 ± 0.3

380 ± 34

  1. LVDP Left ventricular develped pressure, CF coronary effluent, TSA trichostatin A
  2. No significant differences were found between the experimental groups for any of the functional parameters (n = 4–5/per group)
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Molecular Medicine

ISSN: 1528-3658