Fig. 6
KW6002 treatment reversed hyperoxia-induced reduction of the mRNAs for A2AR and eNOS at P12. Retina of OIR and room air was dissected and harvested at P12 in retina after KW6002 or vehicle treatment (P7–12) and A2AR and A1R mRNAs as well as the mRNAs for VEGF and eNOS were determined by qPCR analysis. Compared to the room air group, A1R was affected by neither to hyperoxia or KW6002 treatment (a) whereas the mRNAs for A2AR, VEGF and eNOS were reduced by hyperoxic exposure. KW6002 treatment reversed the reduction of A2AR mRNA and eNOS by hyperoxia (b, c, d). n = 6/group *p < 0.05, **p < 0.01, ***p < 0.001, two-way ANOVA followed by Bonferroni post-hoc test or Kruskal-Wallis test n = 6/group