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Fig. 4 | Molecular Medicine

Fig. 4

From: Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

Fig. 4

Protective effects of IP and NRG-1 were suppressed by the ErbB4 inhibitor AG1478 ex vivo. (a), Representative heart slices stained by TTC, red: the ischaemic area, white: infarct area. (b), the percentage of infarct size/left ventricle (IS/LV%). (c), Histological analysis of heart sections in Langendorff model by hematoxylin and eosin staining. CON: control, IR: ischaemia-reperfusion, IP: ischaemic postconditioning, NRG-1: IR + NRG-1. Data are shown as the mean ± SEM (n = 6). *p < 0.05 vs. IR; #p < 0.05 vs. the same treated group without AG1478

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Molecular Medicine

ISSN: 1528-3658