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Fig. 5 | Molecular Medicine

Fig. 5

From: Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

Fig. 5

The phosphorylation of ErbB4 and the RISK pathway inhibited by AG1478 ex vivo. (a), Representative protein levels of P-ErbB4 and T-ErbB4 by western blotting. (b), Semi-quantification of the density ratio of P-ErbB4/T-ErbB4. (c), Representative protein levels of P-ERK1/2 and T-ERK1/2 by western blotting. (d), Semi-quantification of the density ratio of P-ERK1/2/T-ERK1/2. (e), Representative protein levels of P-AKT and T-AKT by western blotting. (f), Semi-quantification of the density ratio of P-AKT/T-AKT. These protein levels were normalised to GAPDH. CON: control, IR: ischaemia-reperfusion, IP: ischaemic postconditioning, NRG-1: IR + NRG-1. Data are shown as the mean ± SEM (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 vs. IR; #p < 0.05, ##p < 0.01, ### p < 0.001 vs. the same treated group without AG1478

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Molecular Medicine

ISSN: 1528-3658