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Fig. 6 | Molecular Medicine

Fig. 6

From: Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

Fig. 6

Protective effects of IP and NRG-1 abolished by PD980509 and LY294002 ex vivo. (a), Representative heart slices stained by TTC, red: the ischaemic area, white: infarct area. (b), The percentage of infarct size/left ventricle (IS/LV%). (c), Representative protein levels of P-ERK1/2 and T-ERK1/2 by western blotting. (d), Semi-quantification of the density ratio of P-ERK1/2/T-ERK1/2. (e), Representative protein levels of P-AKT and T-AKT by western blotting. (f), Semi-quantification of the density ratio of P-AKT/T-AKT. (g), Representative protein levels of P-p70s6k and T-p70s6k by western blotting. (h), Semi-quantification of the density ratio of P-p70s6k/T-p70s6k.These protein levels were normalised to GAPDH. CON: control, IR: ischaemia-reperfusion, IP: ischaemic postconditioning, NRG-1: IR + NRG-1, PD: PD98059, LY: LY294002. Data are shown as the mean ± SEM (n = 6). *p < 0.05, **p < 0.01 vs. IR; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. the same treated group without inhibitor

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Molecular Medicine

ISSN: 1528-3658