Fig. 1

Transcriptomic analysis in internal jugular vein walls. a Heat map representation of the 924 differentially expressed genes (1408 probes). Each column represents one RNA sample (MS/CCSVI and control jugular walls) and each row represents one gene (probe). Colors represent the expression level fold change: higher-red, lower- green and no difference-yellow. b Enriched biological processes and (c) pathways associated to the 924 genes differentially expressed between MS and control jugular walls. Significantly overrepresented terms (Benjamini test P < 0.05) were selected from DAVID bioinformatics 6.7 by the Functional Annotation Chart resource. *Pathway significantly overrepresented only among up-regulated genes