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Fig. 3 | Molecular Medicine

Fig. 3

From: Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Fig. 3

ELISA indicates that serum SOD, ROS, MDA, IL-1β, and IL-6 are decreased while TNF-α is increased after transfection of miR-181a or si-CRY1. Notes: Panel a, histogram of SOD; Panel b, histogram of IL-1β; Panel c, histogram of IL-6; Panel d, histogram of TNF-α; Panel e, histogram of MDA; Panel f, histogram of ROS; *, p < 0.05 vs. the normal group; #, p < 0.05 vs. the blank and NC groups; the data are presented as the mean ± standard deviation, analyzed by one-way ANOVA; the experiment was independently repeated three times; NC, negative control; miR-181a, microRNA-181a; CRY1, cryptochrome 1; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen; IL-6, interleukin-6; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α

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Molecular Medicine

ISSN: 1528-3658