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Table 3 Upregulation of miR-181a or downregulation of CRY1 decreases the contents of serum urea nitrogen and serum creatinine of CKD rats (n = 10)

From: Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Group

Serum urea nitrogen (mmol/L)

Serum creatinine (mmol/L)

Normal

3.47 ± 0.45

54.28 ± 8.34

Blank

8.39 ± 1.34*

94.39 ± 11.32*

NC

8.25 ± 1.24*

96.24 ± 11.34*

MiR-181a mimic

6.14 ± 0.83*#

70.73 ± 6.78*#

MiR-181a inhibitor

12.31 ± 2.12*#

113.65 ± 12.89*#

si-CRY1

6.06 ± 0.83*#

71.07 ± 6.75*#

MiR-181a inhibitor + si-CRY1

8.17 ± 1.23*

90.21 ± 11.31*

  1. Note: *, p < 0.05 vs. the normal group; #, p < 0.05 vs. the blank and NC groups; the data are presented as mean ± standard deviation and analyzed by one-way ANOVA.; the experiment was independently repeated three times
  2. NC negative control, miR-181a microRNA-181a, CRY1 cryptochrome 1, CKD chronic kidney disease
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Molecular Medicine

ISSN: 1528-3658